The presence of two interacting motifs in the M2 structure raises interesting regulatory possibilities.
The discrimination of all these regulatory possibilities will have wait to the identification of the signaling deficiency promoting the tumorigenesis in Vav1 deficient lymphocytes.
Intragenic miRNAs present unique regulatory possibilities based on functional relationships with their host genes.
A new theory, the so-called binary 'switch hypothesis' is based on the observation that the best studied methyl marks in the H3 tail (lysine 4, 9, and 27) are all adjacent to serine or threonine (potential phospho marks), and discusses the arising regulatory possibilities with regard to gene repression and activation (see Figure 1A; Fischle et al, 2003a).
Now, interestingly, that problem, I think, has been swept under the intellectual carpet because of the relatively facile and widely accepted assumption, which has not been challenged, nor justified, that the combinatorics of transcription factors provide an explosive number of regulatory possibilities - with enough capacity in the system to program anything from a worm to human.
To encode the three regulatory interaction possibilities (synthesis activation, synthesis repression, no synthesis regulation) between two genes i and j, and 2. To represent the strength of the regulatory influence of gene j on i.
While both companies say they expect few regulatory issues, the possibility of political interference still hangs over the deal.
We believe that for regulatory purposes the possibility to get reproducible results is an advantage.
Although no explicit initial discussions were held about the use of company-specific data for regulatory purposes, this possibility was discussed following receipt of the FDA Warning Letter by 23andMe, and it was agreed that the companies could do so.
