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The presence of two interacting motifs in the M2 structure raises interesting regulatory possibilities.
The discrimination of all these regulatory possibilities will have wait to the identification of the signaling deficiency promoting the tumorigenesis in Vav1 deficient lymphocytes.
Intragenic miRNAs present unique regulatory possibilities based on functional relationships with their host genes.
A new theory, the so-called binary 'switch hypothesis' is based on the observation that the best studied methyl marks in the H3 tail (lysine 4, 9, and 27) are all adjacent to serine or threonine (potential phospho marks), and discusses the arising regulatory possibilities with regard to gene repression and activation (see Figure 1A; Fischle et al, 2003a).
Now, interestingly, that problem, I think, has been swept under the intellectual carpet because of the relatively facile and widely accepted assumption, which has not been challenged, nor justified, that the combinatorics of transcription factors provide an explosive number of regulatory possibilities - with enough capacity in the system to program anything from a worm to human.
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This direct interaction between NO signaling and hypoxia signaling is one regulatory possibility.
Only 3%to9%9% of A, B and P mares foaled at age 3 years, which is the regulatory possibility and more or less the biological limit (foaling at 2 years old might be possible).
To encode the three regulatory interaction possibilities (synthesis activation, synthesis repression, no synthesis regulation) between two genes i and j, and 2. To represent the strength of the regulatory influence of gene j on i.
Thus, various regulatory bodies consider possibilities to address this problem via shared use of spectrum.
Furthermore, deterministic ODEs are only one of several mathematical structures used to model gene regulatory networks; other possibilities include boolean networks, Petri nets, Markov chains, stochastic ODEs, and so on.
While both companies say they expect few regulatory issues, the possibility of political interference still hangs over the deal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com