Sentence examples for regulatory population from inspiring English sources

On the other hand, there is very clear evidence that this regulatory population is functionally defective in mice and patients with type 1 diabetes [20] [22].

In mice, although activated murine CD4+ T cells express CD25, the CD4+CD25+ phenotype identifies a largely homogeneous regulatory population.

On the other hand, the regulatory population exerts a positive effect on Teff migration, anergy and death (γ E).

Their persistence in DMD muscle could derive from either clonal expansion or conserved antigen recognition, or from the emergence of a regulatory population.

Another possibility is that 4-1BB stimulanes APCAPC or regulatory population, through 4-1BB or its alternate partner, leading to expression of a suppressive molecule.

We hypothesize that this unusual regulatory population may preclude protective immune responses against Mtb in our cohort of coinfected patients, a topic currently under investigation by our group.

Various regulatory populations of T lymphocytes can modulate inflammatory immune responses and there has been considerable recent interest in the potential for regulatory T cells to modify the outcome of both murine and human malaria infections.

Therefore, CD4+CD25+ Treg appeared to have no effect on the presentation of tumor antigen by DC in this tumor model, possibly suggesting that other regulatory populations that are not affected by PC61 treatment were involved.

However, its contribution to the balance between effector and regulatory populations remains unclear.

We also introduced targeted perturbations into the model that mimicked immunotherapies that modulate effector and regulatory populations.

These clones therefore provide the first opportunity to characterize human Tr cells representative of regulatory populations in autoimmune disease.