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The regulatory logic and the cell fate dynamics of each simple GRN, the latter revealed by mathematical and computational modeling, are elaborated.
The results reveal a remarkable degree of functional plasticity in signaling proteins and pathways, as well as regulatory logic that can be transported to new proteins.
Here I will discuss the molecular underpinnings of these observations and explore the regulatory logic of the developmental fate transitions that lead to the formation of a flower.
These mechanisms follow the same regulatory logic in yeasts and multicellular eukaryotes but the detailed protein interactions are different.
Thus, if the predicted topology permits the inference of the regulatory logic it is correct in 87% ( = 13/15) of the cases.
These applications will require more sophisticated sensing, actuating and regulatory logic than chemical production pathways and may depend on the temporal history of events experienced by the cell.
However, it was possible that the regulatory logic was evolutionarily conserved between these distantly related species.
(The WNT-inhibitory function WIF1 may serve that same homeostatic regulatory logic).
Our goal was to understand the regulatory logic of the NF-κB transcriptional network.
However, the regulatory logic in this case is not absolutely clear.
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This comprehensive analysis allowed us to infer the cis-regulatory logic for most of the CRMs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com