These data provide a direct regulatory link between ubiquitin-dependent protein degradation, actin cytoskeleton, and neurodevelopment.
Interestingly, a paralog of the classical PTS was proposed to function as a regulatory link between carbon and nitrogen metabolism.
Those literature results support the hypothesis of an indirect regulatory link between miR-133a and module 29 genes via SRF.
If so, IFNα may be a very important regulatory link between the innate and adaptive immune responses.
The importance of an input gene in the prediction of the target gene expression pattern is taken as an indication of a putative regulatory link.
In this sense, MMP9 is a direct target of Runx2 in bone tissue, suggesting a regulatory link between Runx2, the expression of MMP9, and cell migration [75], [76].
The PTSNtr proteins (EINtr, NPr and EIIANtr) have previously been suggested to provide a regulatory link between carbon and nitrogen metabolism [3], [4], [5], [6], [11], [80], [81].
Each regulatory link was either repression, activation or an absence of regulation, giving 80 possible 2-protein architectures or motifs (Figure 1).
Though the importance of poly P and the regulatory link between sigE and rel is now well established [17], a number of questions remain unanswered.
We analyzed all possible events at a regulatory link.
This possibly points to a consistent regulatory link between both traits [ 25].
