Also, mapping of the conserved gene ACTBL2 to an RMEL3 intron may represent a meaningful regulatory interrelationship with reflex in the actin cytoskeleton dynamics and cell migration.
Targets of ENV1 and BLR1/BLR2 are for the most part distinct and indicate individual functions for ENV1 and the BLR complex besides their postulated regulatory interrelationship.
Our ongoing studies on heterotrimeric G-protein signaling suggest a regulatory interrelationship between gna1 and gna3 as well as an interconnection to the light response pathway (data not shown), which warrants further detailed investigations.
Complementary investigation of early and late light response revealed that ENV1 represents a crucial node in light signal transduction and exerts its function in part via the regulatory interrelationship with the phosducin like protein PhLP1, as well as GNB1 and GNG1.
Detailed investigation of a regulatory interrelationship of these components with ENV1 under conditions of early and late light response indicated a transcriptional mutual regulation between PhLP1 and ENV1, which appears to dampen nutrient signalling during early light response, presumably to free resources for protective measures prior to adaptation of metabolism to light.
The interrelationships between regulatory design on one hand and optimal patterns of operation on the other suggest the investigation of operating principles that complement design principles, like a user's manual complements the hardwiring of electronic equipment.
For many years, the study of the regulation of the SOS network was complicated by both the complexities of the responses and the interrelationships of the key regulatory elements.
Tamoxifen-resistant breast cancer cells also showed complete insensitivity to growth inhibition by TGFβ and reduced sensitivity to the growth inhibitory effects of retinoic acid, supporting interrelationships among the cell regulatory pathways utilized by these three growth-suppressive agents [ 65].
Noteworthy, single miRNAs can regulate the expression of hundreds of protein coding target mRNAs and, conversely, the expression of a single gene can be regulated by multiple miRNAs, indicating the complexity of miRNA-mRNA interrelationship and the great regulatory potential of miRNAs [ 13, 21, 22].
Insightful findings are reported on the interrelationships among modal competition, market regulatory regimes, toll pricing schemes, and urban configurations as well as their implications in practice.
