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The rapidly increasing amount of biomedical publications is a key resource for the automated extraction and inference of relations between biomedical concepts such as protein-protein interactions or regulatory interrelations.
This unexpected absence of predicted MMP13 expression may be an indication for a more complex regulation of MMP13 transcription, exceeding the already known regulatory interrelations.
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CluePedia provides a comprehensive view on a pathway or process by investigating experimental and in silico data from different perspectives: gene interrelations, miRNAs regulatory aspects, protein protein interactions, as well as the functional context, in conjunction with ClueGO (Bindea et al., 2009).
Thus, our findings suggest that, within the complex interrelation of regulatory cytokines, IL-6, IL-10 and TNF-α may not play a key role in the inflammation in bronchial tissues in horses with RAO.
Overall, our observations shed a new light on a possible role of Δ40p53 in the regulation of p53 activity in stem and progenitor cells, contributing to either enhance or inhibit p53 function in a manner which is exquisitely regulated by the relative levels of each isoform and their interrelations with p53 regulatory systems such as Hdm2/Hdmx.
Inter-layer relationships are characterised by vertical control and communication, but the full regulatory structure also includes significant horizontal interrelations as well as self-regulation.
Despite their interrelations, signaling, protein-protein, gene regulatory, and metabolic networks frequently have been modeled independently in the context of well-defined subsystems.
Gene regulatory networks (GRNs) are used to indicate the interrelation among genes in the genomic level [ 2].
The information available after decoding the genome of the human species and many others is opening the possibility of new approaches to target thousands of protein interactions critical for a continuously increasing list of genetic and infectious diseases and pathologies, and to understand complex regulatory pathways and interaction networks describing cell function and interrelation.
Regulatory investigations.
Regulatory simplification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com