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Dissecting the global transcriptional profiles of immune cell populations may provide insights into this regulatory interplay.
However, wet lab experiments targeted at the discovery of the regulatory interplay between transcription factors and binding sites are expensive.
This refractoriness has been experimentally validated in the wing primordium, mediates the regulatory interplay between Notch and Wg and promotes the formation of mutually exclusive domains in terms of their activities.
Signaling cascades governing flagellum biosynthesis, one of the major virulence traits in TP, have previously been characterized and revealed a complex regulatory interplay between signal transduction and virulence gene expression [15], [16].
Recently, the emerging multi-dimensional genomic dataset has provided unprecedented opportunities to study the cross-layer regulatory interplay.
Aside from this proposed regulatory interplay between IFNs, the actual expression of a new player, IFNL4, could itself provide explanation for the elevated baseline ISG expression.
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Our pilot study suggests for the first time that a signature based on T-UCR expression is associated with good outcome in non infant patients diagnosed with metastatic NB, and lets us assume putative complex regulatory interplays between T-UCRs and microRNAs in neuroblastoma.
Dysfunction in the regulatory capacity or interplay of these systems, as a potential consequence of dispositional risk or physical, chemical or emotional challenges, might plausibly exacerbate symptoms of CFS.
As a matter of fact, pre-mRNA splicing is a finely orchestrated process involving many exonic and intronic regulatory elements, whose interplay depends on the specific gene context [6,7].
Taken together, we have identified the function of a novel gene C7ORF41 that forms interplaying regulatory network in TPA-induced signaling and promotes leukemic and normal megakaryocyte differentiation.
Here, we review the evolutionary origin, mechanistic underpinnings, and regulatory consequences of this interplay between RNAP and nascent RNA structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com