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Ca(2+) signaling, which halts both anterograde and retrograde mitochondrial motion, serves as one regulatory input.
Previous computational studies have suggested that the capillary blood flow oscillations frequently observed in vivo can originate spontaneously from the non-linear rheological properties of blood, without any regulatory input.
Collectively, these data suggested that the role of these two sites in regulating enzymatic activity was much more complex and may have other regulatory input besides phosphorylation regulation.
As such, the 5-HTTLPR may represent a classic susceptibility factor for affective disorders by biasing the functional reactivity of the human amygdala in the context of stressful life experiences and/or deficient cortical regulatory input.
The canonical Wnt signaling regulatory input for ventral-specific gene expression appears to be lacking in cephalochordates (this study) [17] and has likely been co-opted in vertebrates.
While it explains the systematic variation of Hunchback with Bicoid through the sigmoidal input/output relation, our model would treat any other regulatory input influence as an 'extrinsic' noise source.
Many biologic systems have the ability to perceive and respond to functional challenges by adapting, but the physical signal which dominates the regulatory input has been difficult to identify.
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Changes in expression levels have to be mediated by changes in either production or decay rates, and the literature contains several specific examples of noncoding mutations affecting for instance production rates [42], mRNA processing rates [43], [44], the shape of the cis-regulatory input function [45], [46], [47] and mRNA decay rates [48], [49], [50].
The relationship between polymorphisms affecting the shape of the cis-regulatory input function is less intuitive.
This means that steepening the cis-regulatory input function causes in general a given set of regulatory polymorphisms to have more distinct phenotypic signatures.
In all six models the transition from a hyperbolic to a sigmoidal cis-regulatory input function causes a dramatic increase in the frequency of detected trans-acting determinants.
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