Exact(1)
Price et al.[ 11] have hypothesized that as the amount of regulatory information required to specify an optimal expression pattern increases, evolving the optimal expression profile separately for each gene becomes more difficult, whilst creating an operon does not.
Similar(7)
Dose-dependent differential gene expression provides critical information required for regulatory decision-making.
This field provides the information required for the process of cell differentiation to occur by being dynamically coupled to a signal transduction mechanism that, in turn, acts directly upon the gene regulatory network (GRN) underlying cell-fate decisions within cells.
Others explain operon formation by the fact that new operons reduce the amount of regulatory information that is required to specify optimal expression patterns and therefore operons should be likely to evolve when the regulation is complex [ 6].
The study protocols, informed consent and other information requiring pre-approval were reviewed and approved by Institutional Review Boards Institutional Review Board Services and Optimum Ethics Review Boardd) in accordance with Canadian regulatory requirements.
Ortholog-specific signatures were also evident from the results of hierarchical clustering analysis, reflecting the additional non-species-specific or non-lineage-specific regulatory information that may be required for the stress-associated function of the orthologs in conjunction with the spatially conserved core modules.
Some studies have found a positive relationship between intergenic sequence length and expression diversity between tissues, and concluded that genes under greater regulatory control require more regulatory information in their intergenic sequences.
The general interpretation, based on the current understanding of gene regulation, is that genes under greater regulatory control require more regulatory information, resulting in a longer upstream intergenic sequence [4], [6].
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