Sentence examples for regulatory grammar from inspiring English sources

STAP was applied to several important analysis tasks, including comparison of TF binding profiles, identification of TF interactions, studying the effect of binding site arrangement (regulatory grammar) and prediction of TF target sequences.

Motivation: Understanding the transcriptional regulation of a gene in detail is a crucial step towards uncovering and ultimately utilizing the regulatory grammar of the genome.

These results suggest a motif regulatory "grammar" governed by physical constraints that dictate the in vivo spatial arrangements and frequencies of combinations of motifs, which is consistent with a previous report [ 26], and may uncover some of the non-canonical sequence determinants that underly disease-associated SNPs.

Examination of these CREs permitted the definition of a simple cis-regulatory grammar rule associated with high-level expression.

To improve upon thermodynamic modeling attempts to unlock key aspects of cis-regulatory grammar, we should recognize a need for sensitivity analysis and a thorough exploration of parameter space.

Our study highlights the need to consider the activity of "off target" sites in generating novel elements, particularly because for Hairy at least (and likely other factors that employ the same cellular machinery) they are "shovel ready" and not constrained by complex cis-regulatory grammar.

Furthermore, the Dorsal protein, when itself acting as a long-range repressor, is dependent on neighboring Cut and Dri transcription factor motifs to function, indicating that long-range repression complexes may require specific cis-regulatory grammar (Cai et al., 1996; Nibu et al., 2001).

The genome-wide analysis of repression by Hairy revealed an unexpected facet of chromatin activity and highlights the need to consider the activity of 'off target' sites in generating novel elements, particularly because for Hairy at least (and likely other factors that employ the same cellular machinery) they are 'shovel ready' and not constrained by complex cis-regulatory grammar.

This may be due to operating distance flexibility, cis-regulatory module grammar, or neutral mutations in site positions that correspond to low-information motif columns.

GBNet employs a Bayesian network to represent the grammar (regulatory rules) of cis-regulation.

One of the major challenges in modern biology is the deciphering of the regulatory language, syntax and grammar, encoded in the genome, that directs spatio-temporally restricted gene expression.