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CircRNAs were expressed in a spatio-temporally specific manner, suggesting their regulatory functional potentials were overlooked previously.
These non-protein-coding genes, along with some CGs, play a variety of regulatory functional roles.
Disease-related gene classes are 4-fold enriched in regulatory functional categories vs. random genes (Figure 7).
However, keeping in mind the other important regulatory functional roles performed by CGs, their annotation in the genome is equally important and should not be ignored.
Therefore, in the present work, we tested all resistin regulatory, functional and also emerging evolutionary concepts in different human and mouse models aiming to explain the Resistin Paradox decisively.
Interleukin 11 signaling has also been regarded as regulatory functional in 3T3-L1 adipocytes [ 20].
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Here, we have generated a Boolean network model based on detailed cis-regulatory functional data connecting 11 haematopoietic stem/progenitor cell (HSPC) regulator genes.
Here, we have generated a regulatory network model for HSPCs based on comprehensive experimental data, which represents the most complex mammalian network model to date anchored on cis-regulatory functional data.
Buzeli et al (2002) identified two cis-regulatory functional domains that are important for the spatially-regulated activation of BiP expression under normal plant development by promoter deletion analyses [ 52].
Noh et al (2003) also found that the expression of BiP genes in A.thaliana appeared to be regulated by cis-regulatory functional domains, which are ERSE and UPRE [ 53].
Muñoz, M. E. & Ponce, E. Pyruvate kinase: current status of regulatory and functional properties.
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