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Thus we get valid links and concrete regulatory directions at the current conditions.
Thus, we may derive valid links and concrete regulatory directions at the two gain thresholds from the additional Figure 7-A in Additional file 9.
For every gene set, we also calculated the ratio of up-regulated regulatory events over the total regulatory events within the gene set to indicate their regulatory directions.
Secondly, the proposed method tackles one of most important problems from the perspective of signal processing theory, namely, the determination of regulatory directions between candidate gene pairs.
An associativity measure is proposed to define the regulatory strength/connectivity, and a phase-shift metric determines regulatory directions among components of the reconstructed networks.
By comparing two Motifs, II and III, and by examining the regulatory directions between the miRNAs and TFs, we found that miRNAs tended to be significantly regulated by TFs rather than regulate TFs.
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If the bill were enacted, the race to the regulatory depths would continue, and the nation would be headed in exactly the wrong regulatory direction.
It also promised a "proactive stance on future regulatory direction and robust controls" and set a series of financial "ambitions", designed to bolster shareholder returns.
Over-correction in the regulatory direction might do opposite harms; yet the robber-baron mentality of speculators cannot be allowed to destabilise the entire economy on the grounds that nothing but the profit motive counts.
Nevertheless, the future regulatory direction remains uncertain, with some advocates trying to force a return to a vertically integrated monopoly structure and others striving to improve regulatory rules within a partially regulated, partially deregulated system.
The background and scope of basic PSR guidelines are described, and a summary of technical criteria for aging management, which shows a regulatory direction for PSR, is also presented.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com