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The neuronal cells compensate for the increase in volume by active depletion of intracellular osmotic solutes (so called 'volume regulatory decrease') [ 4, 5].
In addition to volume regulation (specifically volume regulatory decrease), they are thought to be involved in several cellular processes including proliferation and apoptosis (Stutzin and Hoffmann, 2006).
In the metastable phase that precedes death, hepatocytes respond to the progressive increase of intracellular Na+ with the stimulation of the volume regulatory decrease mechanisms, that is, activation of the K+ channels and K+ efflux.
VRACs are also proposed to transport, albeit at lower rates, a range of structurally unrelated, charged and uncharged, small solutes, including the organic osmolytes (also involved in volume regulatory decrease) taurine and sorbitol (Strange et al., 1996; Kirk, 1997).
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Increasing noise increases the probability of escaping from existing regulatory constrains; decreasing noise decreases the possibilities of adaptation.
Roles in regulatory volume decrease and erythroid differentiation.
When exposed to diluted seawater (osmolalities from 895 to 712 mosm kg−1), both cell types first swell and then undergo a shrinkage known as Regulatory Volume Decrease (RVD).
They were shown to regulate cell volume changes, as well as regulatory volume decrease in a large variety of cell types, including hepatocytes, lymphocytes, fibroblasts, myocytes, and various tumor cells.
DEX accelerated, and CCD slowed, the regulatory volume decrease after hypotonic exposure.
Preincubation with 30 nM ouabain for 4 h did not detectably change Na level, the regulatory volume decrease (RVD) or the actin cytoskeleton of TM5 cells, but did inhibit hypotonicity-elicited ATP release.
When placed in a hypoosmotic milieu, astrocytes are able to activate a mechanism known under the term of "regulatory volume decrease" which impedes the influx of water, regardless if the osmotic gradient is unfavorable.
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