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In M. abdita, tll and hkb play similar roles, although the amount of their respective regulatory contributions is altered compared to D. melanogaster.
This suggests the possibility that MIR elements have been conserved among mammalian genomes, at least to some extent, by virtue of their regulatory contributions.
These observations suggest that temporal regulation of y, yar, and ac might be linked, a possibility supported by previously identified regulatory contributions of other ncRNA genes (Ogawa and Lee 2002; Martens et al. 2004; Petruk et al. 2006; Martianov et al. 2007).
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Hence, lipids have no regulatory contribution to this process; they simply adapt their shape passively for filling space between otherwise autonomous protein machineries.
The regulatory contribution of MITF may be masked by the combined contribution of these other regulators.
Clearly, further studies are needed to determine if Zip7 and/or Zip9 facilitate Zn mobilization from the Golgi apparatus for import into ZnT2-associated secretory vesicles and if so, what the regulatory contribution of the Golgi apparatus is in mammary gland Zn secretion.
The data to date suggest that an overall decrease in spliceosomal activity may induce overproliferation of germline, although the mechanism of splicing factor regulatory contribution remains unknown.
Dhh has not previously been functionally linked to skeletogenesis but this opens the possibility of regulatory contribution, perhaps co-operating with Ihh.
In addition to the identification of cis- and trans-factors, we described the relative regulatory contribution each of those factors plays by means of a KS p-value.
The basic model that we consider in this paper is additive, i.e. the cooperative regulatory contribution of different nodes is a sum of the contributions from each node.
In this respect, the negative effect of all three photoreceptors on transcription of cre-1 after 40 hours (Additional file 2: Dataset 1) indicates that their regulatory contribution to CCR is mediated by the WCC via VVD and not (only) subject to photoadaptation.
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