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From lines 20 to 31, for every valid regulatory connection in the connectivity matrix, the CMI of the genes with every other gene is evaluated using (7) and if the value is below the user specified threshold (Th) the connection is deleted.
While the 147 I/U-DEGs of K.p.-infected wounds barely made any regulatory connection amongst themselves, the 94 I/U-DEGs of P.a.-infected wounds connected into a 25-molecule regulatory network in which the major hubs were STAT1 and IRF7, with each having 16 direct regulatory connections.
As shown in Fig. 2C, the regulatory connection between PI4KIIα and EGFR/p-HER-2 is also present in primary isolated breast cancer cells.
After several weeks of optimizing my techniques, it started to seem as though the link I was exploring – a regulatory connection between ABL kinases and SLC7A11 – might not exist after all.
Our results reveal a novel regulatory connection between nutrient-sensitive glycosylation and NRF2 signaling and provide a blueprint for future approaches to discover functionally important O-GlcNAcylation events on other KLHL family proteins in various experimental and disease contexts.
In particular, two elements stand out: the groundbreaking activity developed by the Standing Conference of Ministers of Education (SCME) since 1959, and the regulatory framework that led to the European Cultural Convention in 1954 (a soft regulatory connection, based on the willingness of the signatories to cooperate).
Similar(19)
Some lawmakers question whether a consultant's regulatory connections helped it secure contracts.
"I wanted to go out and understand how business was done without regulatory connections," he said.
However, the specific binding sites that mediate and define these regulatory connections are themselves often subject to rapid turnover.
They have also long bounced between D.C. and Wall Street, using their political and regulatory connections to maximize their earning power in the financial world.
Here we use mathematical modeling to study the dynamics of gene regulatory circuits to advance the ability to infer regulatory connections and logic function from experimental data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com