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By enumerating all possible regulatory configurations from the driver node, we identify two types of motifs associated with the toggle switch that is captured by the existence of bistable states.
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We conclude by proposing a generalizable framework for regulating emerging process-based technologies in safety-critical industries in which the optimal regulatory configuration depends on the industry structure (number of firms), the performance and safety requirements, and the sources of technological uncertainty.
Herein, we sought to detail the transcriptional regulatory configuration of PPARγ-RXR-DNA interaction on a genome-wide scale using an established ChIP-PET sequencing approach.
That is, the model is first solved to identify a potential regulatory configuration represented by a binary solution (i.e., set of values of the binary variables).
Along these lines, Kim et al. have shown that the similarities of hPSCs and some tumor-associated signatures are contributed by a distinct MYC regulatory network configuration.
Another is the configuration of regulatory genes that maintain the state in a stable manner.
For example, the two human genes SIRT3 and PSMD13, are linked in divergent configuration sharing regulatory mechanism [ 40].
The results provide important information that can be used when choosing system configurations to meet regulatory requirements and financial constraints.
Recent initiatives to combine several compatible heterologous gene regulation systems have exemplified that complex artificial gene control configurations such as regulatory cascades and networks will develop in the next years from concept studies to a therapeutic reality.
This approach links the gene activation probability to all possible molecular configurations of the regulatory sequence, representing different combinations of free and bound binding sites.
For example, it does not take into account the dynamical effects of the enhanceosome assembly [ 25, 26], which might influence the relative probabilities of different molecular configurations of the regulatory regions.
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