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Three different control systems are compared: (1) typical basic regulatory, (2) regulatory control of the product size attribute, and (3) model-based predictive control.
Collectively, lncRNAs are often seen as 1) regulatory, 2) generated directly (by transcription from TE promoters) or indirectly by TEs, and 3) because of their evolutionary instability and malleability, sources of evolutionary innovation [ Rebollo et al. 2012; Cowley and Oakey 2013; Kapusta et al. 2013]).
The main findings are 1) the changes at wdw have sex- and region-specific effects and could therefore be regulatory, 2) the wdw locus appears to be a co-regulator of cell size and cell number, and 3) the wdw locus has evolved different wing width effects in three species.
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Abbreviations: NB, neuroblastoma; SRR2, Sox2 regulatory region 2; mCMV: Murine Cytomegalovirus; GFP: Green Fluorescence Protein.
SPL9 is demonstrated to be a nitrate regulatory hub10.
The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells.
The utility of these methods is their ability to find novel regulatory interactions10 and even novel necessary regulatory genes11.
Mining regulatory 5′UTRs from cDNA deep sequencing datasets.
TEs copy themselves in the genome and are co-opted to form new regulatory elements1,11,12, and contribute to the rewiring of gene regulatory networks6.
Mmi1 also promotes alternative polyadenylation and transcription termination of meiotic mRNAs and regulatory lncRNAs34,35,36.
The human papillomaviruses (HPV) genome also contains G-quadruplexes that can carry out regulatory functions5.
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