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SUMOylation of transcriptional regulators results in alterations to the transcription regulation of individual genes, while the SUMOylation of epigenetic regulators brings about long-range chromatin remodeling, and hence global changes in expression.

The combination of GPCR, G proteins, and their regulators results in many diverse signaling outputs.

At the next stage, acquisition of mutations in epigenetic regulators results in transformation of pre-LSCs in LSCs.

The interaction of these core components and modulation by additional regulators results in an approximately 24-h period.

In addition, several reports have proposed that deregulation of cell cycle regulators results not only in proliferative advantages, but also in increased tumor progression and aggressiveness traits [ 19].

For example, reversible phosphorylation is implicated in cell cycle, cell growth, apoptosis and signal transduction (1, 2); methylation at certain residues of histones can activate or repress gene expression (3); and SUMOylation of transcriptional regulators results in the inhibition of gene transcription (4).

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The actor Danny Glover thought so, and he took his case to the public and city regulators, resulting in a citywide crackdown on wary cabbies in the late 1990s.

Compounding the Sands's legal headaches in China, several of the company's subsidiaries came under investigation by Chinese regulators, resulting in a $1.6 million fine, according to Chinese and American corporate records.

"Your substantive feedback on our proposals during the seven-day comment period, along with discussions with our global regulators, resulted in clarifications and revisions to those proposals".

Ancestral reconstructions of the recruitment of other three transcription regulators resulted in an evolutionary history that is less clear.

LeMoNe infers for each module the most significant regulators, resulting in opposite characteristics of the degree distributions.

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