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The regulator sequence may play a crucial role in regulating the methylation of the insulator sequence, and hence in regulating insulator function.
However, this putative regulator sequence was interrupted by a copy of the IS Bm1 insertion sequence in S. medicae.
This region is conserved in all completed Burkholderia genomes and Trépanier et al. [ 27] showed that penR controlled the transcription of the class A beta-lactamase penA with a putative binding site mapped to a region 130 bp upstream of the beta-lactamase, directly adjacent to the regulator sequence.
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These results will also be of great help in ongoing efforts for genome wide analysis of Hox binding sites and for investigating direct binding of Hox and Hox co-factors to regulator sequences.
Several regulator sequences have been found within these motifs.
Furthermore, three putative promoter and regulator sequences in the U2 snRNA gene have been found.
The GC content of DNA sequences was found to be correlated to the intrinsic nucleosome occupancy in yeast and in Caenorhabditis elegans, and a high GC content was found at human regulator sequences enriched in well-positioned nucleosomes.
In the case of the transcription regulators the separation remained clear, however with higher e-values due to a short length of the regulator protein sequence.
* PVL, Panton-Valentine leukodin; CA-MRSA, community-acquired methicillin-resistant Staphylococcus aureus ; agr, accessory gene regulator; ST, sequence type; CC, clonal complexes; spa CC, spa clonal complexes.
After comparison of transcriptional regulator gene sequences from the P. multocida genome with other DNA sequences at GenBank, we identified two genes (i.e., Pm0762 and Pm1231) uniquely present in P. multocida.
We examined the conservation pattern of the cell invasion site's known regulator across sequenced apicomplexans.
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