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Prolylcarboxypeptidase encodes a lysosomal enzyme and is a regulator for both renin-angiotensin system and the kallikrein-kinin system.
AhR is a regulator for both LTi and NCR+ ILC3s.
TRPV4 acts as a regulator for both, the microtubule and the actin.
The murine transmembrane glycoprotein CD83 is an important regulator for both thymic T cell maturation and peripheral T cell responses.
We further demonstrated that menin is a crucial regulator for both active and repressive histone 3 modifications in the Hoxa9 locus.
Conversely, histone methylation is a key regulator for both activation and inactivation of transcription.
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CD56+ T cells alongside NK cells as well as NKT cells have been considered as frontline innate immune effectors and potential regulators for both innate and adaptive immune responses against microorganisms including viruses [24], [29], [30].
PGD2 and PGE2 receptor signaling emerged as key regulators for both innate and adaptive immune response.
The top upstream regulators for both datasets are presented in Table 5 and all identified upstream regulators are presented in Additional file 5: Table S5.
Proneural transcription factors are thus critical regulators for both the initiation of neuronal differentiation and the specification of neurons into distinct regional subtypes.
Receptors for prostanoids emerged as key regulators for both innate and adaptive immune responses, since they are widely expressed throughout the immune system, and function at multiple levels in connecting the innate and adaptive immunity [ 16, 24].
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