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A frequent goal in eQTL hotspots studies is to determine a master regulator, i.e., a transcript that regulates the transcription of the other traits mapping to the hotspot.
Therefore, these two bacterial cysteine degradation systems (i.e., YhaM and CcdA/CdsH) that catalyze the same cysteine-decomposing reaction, share the same transcriptional regulator (i.e., YbaO/CcdR/DecR).
If σ i 2 is the noise level of regulator i and R ij is the Pearson correlation in the fluctuations of regulators i and j, then this composite regulator has a total variance σ r 2 = ∑ i c i 2 σ i 2 + ∑ i ≠ j R i j σ i σ j.
Regulator was the name of the regulator, i.e. a TF or a miRNA.
Its purpose is two-fold: first, it can be used to infer the activation state of a putative regulator (i.e. whether the regulator is activated or inhibited).
It is possible that the expression variance for these genes metZ, metW and metV is better explained by a different regulator, i.e Fis instead of only sigma70.
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A dedicated algorithm was computed to automatically provide potential upstream regulators (i.e., output candidates) from lists of regulated targets (input lists).
Transcriptional network information for E. coli, including regulators (i.e., sigma factors and transcriptional factors) and downstream regulated genes, were obtained from RegulonDB 8.0 [ 33] (http://regulondb.ccg.unam.mx).unam.mx
Although this is correct for current processors which use off-chip voltage regulators (i.e., a single regulator for all cores on the same chip), which set all sibling cores to the same voltage level [5], it does not fully capture the range of control opportunities available.
We show that B. recurrentis can bind via its surface expressed HcpA molecule to human complement regulators, i.e. CFH as well as CFHR-1, and in parallel to plasminogen/plasmin.
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