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These proteins identified are involved in a variety of processes, including redox homeostasis, cell wall modification, signal transduction, cell defense and carbohydrate metabolism, indicating a complex regulative network in the apoplast of seedling roots under H2O2 stress.
However, due to the complex regulative network of miRNAs, it is highly possible that miR-34a can modulate multiple cellular pathways simultaneously in bladder cancer.
However, due to the complex regulative network of miR-34a, further study is required to explore other mechanisms of miR-34a in bladder cancer.
In this study, we explored the regulative network of miR-34a in bladder cancer and firstly reported that HNF4G is a direct downstream target of miR-34a.
It is believed that multiple members of a specific gene family that form a large regulative network to control complicated physiological processes were a result of the long evolutionary history of a particular species.
In fact, the regulative network of miRNAs is quite complex, we could not exclude the possibility that other miRNAs are involved in the regulation of HNF4G in bladder cancer [ 24] or miR-34a could modulate bladder cancer through other pathways.
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Larger scale analysis now made available by a functional genomics approach provides a more accurate understanding of the complex regulative networks that sustain the molecular mechanisms responsible for normal development.
Our first-principles modeling approach includes the metabolic and regulative networks that are believed to have a large impact on growth.
The existence and developmental potency of Stat3 null ES cells highlights the regulative nature of the naïve pluripotency network (Nichols and Smith, 2012).
The mechanisms of myocardial depression in human septic shock involve a complex network of vasoactive, Ca2+-regulative and inflammatory mediators [ 12- 15].
Institutional factors such as strong nationalism, the state's entrenchment in the economy, political cognitive and political normative factors, regulative uncertainty, professional associations' roles, and the importance of business and social networks are deeply reflected in China's e-business development pattern.
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