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D.A. Weisblat (1988) Equivalence groups and regulative development.
This is an essential, albeit transient, attribute of cells in embryos that undergo regulative development.
Regulative development is common among Metazoa, and is also observed in other Ecdysozoa, including Arthropoda.
This was surprising since mammalian embryos are thought to undergo regulative development.
We have extended this approach to living embryos and into the additional dimension of time, to study the regulative development of the mouse ICM.
Therefore, testing whether regulative development occurs in planarian embryos, for example, may help us identify key differences crucial to preserving regenerative abilities into adulthood.
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Together, these findings suggest that the retention of a regulative mode of development at late stages by amniote embryos (that allows the formation of the types of monozygotic twins that arise relatively late in development, including Siamese twins) evolved through novel uses of an ancient pathway, involved in both mesendoderm development and left right asymmetry, but in slightly different ways.
The ability of higher vertebrate embryos to retain a regulative model of development until such a late stage strongly suggests that localisation of maternally inherited determinants is not an essential component of the mechanisms specifying embryo polarity (Stern and Downs, 2012).
The interplay between these different factors explains the robustness and the highly regulative aspects of preimplantation development.
The functional significance of miR-9 is evidenced by its regulative role in neurogenesis, development, and apoptosis.
Indeed, a greater role for regulative interactions in early development has been demonstrated in another rhabditid, Acrobeloides nanus (Tylenchina) [ 11, 12].
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