As we will see, despite incomplete and inaccurate data and a complex phenotype, the computational study of the evolution of gene regulation relevant for stem cells/pluripotency confirms observations from the literature and reveals some interesting insights as well.
The discovery that Jarid2 regulates PCP/Wnt signaling in addition to its canonical role in PRC2 highlights an important intersection between cell signaling and chromatin-based regulation, relevant for understanding the interplay between pluripotency and differentiation.
Biosensor tests mimicking field conditions point to global regulation being relevant for biosensor performance; thus, this global regulation must be taken into account when designing whole-cell biosensors.
The proposed framework is widely applicable to different basins, and provides foundations for using scaling laws as empirical tools for inferring temporal changes of hydrological regulation, particularly relevant for identifying and managing hydrological consequences of environmental change.
Since only the STAT1 mRNA levels were found to be predictive of unfavorable outcome, we postulate that only the transcriptional but not the posttranscriptional regulation is relevant for the prognosis.
Although the variation in u-ENaCγ was considerable, this suggests that NO interferes with the transport via ENaC with an AVP-dependent mechanism, supporting the assumption that the AVP-cAMP pathway of ENaC regulation is relevant for sodium homeostasis in humans [ 28, 32].
In addition to the above discussed potential role of the multispanning membrane protein TM9SF4 in structural re-arrangement of gill epithelia, its hypercapnia induced up-regulation might be relevant for cellular acid-base regulation.
Given the complexity of these programs, we briefly discuss rules and regulations that are relevant for this study and how eligibility for each coping strategy is determined.
Therefore, analysis of their expression regulation is not relevant for understanding of the biology of cervical carcinoma cells.
Some miRNAs are not directly implicated in EMT-TF regulation but are relevant for metastatic dissemination, either suppressing or promoting metastasis.
