Mosser and Edwards [37] have recently proposed three major populations of macrophages based on three different homeostatic activities; host defense (classically-activated macrophages), wound healing (wound-healing macrophages) and immune regulation (regulatory macrophages).
As an attempt to account for transcriptional regulation, regulatory interactions were introduced in models by translating them into Boolean rules (Covert et al., 2001).
The M1 subunit possesses a binding site for enzyme regulation (regulatory subunit), and the M2 subunit is involved with RR activity (catalytic subunit).
In [ 13] it was extended in order to incorporate transcriptional regulation (regulatory FBA, or rFBA); further developments included also signal transduction networks (integrated FBA or iFBA [ 14], and integrated dynamic FBA or idFBA [ 15]).
They also recognise the need to improve their own staff's abilities to 'understand the nature and needs of the SMEs that they regulate', to 'reduce compliance burdens by changing regulations or regulatory policy' [28].
And the relative vagueness and opacity of the regulations under regulatory reform seem to lend themselves to capture.
One limitation of this study is the small sample size, and the fact that regulations and regulatory regimes differ across jurisdictions.
What happens is that there are many regulations and regulatory bodies, government regulations, EU regulations, and so forth that we have to work with over the next few months to get everything set up and we are in the middle of that process now.
If each state adopts its unique set of shale gas regulations, a regulatory race to the bottom is possible.
