The process lacks any clear regulations or permitting process.
As KIT (and most likely ETV1) overexpression is rarely caused by gene amplification, it is postulated that other mechanisms such as transcriptional or translational regulation, or processes that act on RNA stability may be involved (Tabone et al, 2005).
It's use may be associated with a set of principles, the exercise of legitimate authority through law and regulation, or processes for ensuring accountability and managing risk within organizations [ 1, 2].
Importantly, the timescales of enzyme change predicted by the variational principle may overlap with timescales of substrate kinetics, suggesting that our findings should be interpreted under the assumption that enzyme changes may result from a combination of slow (e.g., transcription-translation and degradation) and fast (e.g., allosteric regulation, or phosphorylation) processes.
A new administration could freeze any pending regulations or reverse them, a process that could take months.
Comparing PPI networks of evolutionary distant species can help to understand the regulation of a specific function or process, which the sequence comparison alone cannot explain.
It still remains to be tested however, whether or not MicA-dependent processing of the luxS mRNA is essential for CyaR-mediated regulation or if the process can be by-passed.
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