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The synergistic regulations of modules were then validated by searching target-mRNAs regulated by multiple miRNAs in miRNA synergistic modules.
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The synergistic regulations of module genes were verified by reviewing miRNA target databases and previous studies.
To determine differential regulation of modules within other expression datasets we first identified phenotype dependent expression changes for each sample using an absolute fold change filter of greater than 2. To generate fold changes against which we could filter each gene was scaled to a baseline intensity value.
Those results demonstrate that the ZEB1 factor is essential for the regulation of module 25 genes.
Genes belonging to these modules were related with various metabolic processes (Module J, K, and L), transmembrane transport (Module M), regulation of proteolysis (Module J), neuron homeostasis (Module N), and other biological processes/functions (Table 2).
Together, our results suggest that PCN regulates development of secondary vascular tissues, potentially through regulation of transcriptional modules associated with cell differentiation and/or hormone-mediated processes.
The 12 TRs of these modules are predicted by the TRN to be putatively responsible for coordinating down regulation of these modules with other transcriptional changes during the N-starvation response.
Many of these mRNAs encode functionally related proteins, supporting a model for coordinated regulation of posttranscriptional modules by specific RNA-binding proteins.
This negative effect is compounded annually; therefore, optimizing thermal regulation of PV modules and battery bank room conditions is essential in maintaining excellent operating temperatures.
We used chemical kinase inhibitors to identify the pathways involved in the regulation of gene modules in response to stimulation.
Thus, it is possible that transcriptional regulation of these modules may also be correlated with RR-WCR's behavioral characteristics (e.g., elevated mobility).
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