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The regulations of alternative splicing in the 11 DAS genes may play important roles in the cell cycle regulation.
Tighter regulations of alternative therapy practices are needed.
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Splicing mechanism is very carefully regulated as aberrant regulation of alternative splicing in human has been implicated in various diseases [ 30, 31].
We therefore postulate that the mechanism by which Eae23b regulates EAE is through regulation of alternative splicing of ZEB1 which in turn regulates IL2.
Clk2 may be involved in regulation of alternative splicing [ 18] and our result indicates that Clk2 itself may be alternatively spliced.
Venables, J.P. et al. Cancer-associated regulation of alternative splicing.
Mechanisms and regulation of alternative pre-mRNA splicing.
Matveeva, E. et al. Involvement of PARP1 in the regulation of alternative splicing.
Österberg, S., Peso-Santos, Td & Shingler, V. Regulation of alternative sigma factor use. Annu.
Wood, A. J. et al. Regulation of alternative polyadenylation by genomic imprinting.
Luco, R. F. et al. Regulation of alternative splicing by histone modifications.
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