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The actual availability of the technology, however, cannot be described in any clear-cut way, as it will be determined by the laws and regulations of a given country, the international and national guidelines of the professional associations, and the prevailing social and cultural norms in a population.
In all combat sports involving hitting (also using weapon) or kicking, youth younger than 18 years should wear protection on teeth, genitals and breasts (girls) and other body parts according to the regulations of a given federation.
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Furthermore, upstream regulation of a given miRNA can involve multiple regulators at different steps of miRNA biogenesis.
The intensity of the node color indicates the degree of up- (red) or down- (green) regulation of a given gene.
Ultimately, disruption of an enhancer in the context of whole genome is needed to test its importance for the regulation of a given gene in vivo.
Regulation nodes collect activity signals of all of the genes involved in regulation of a given gene at some point along the path from DNA to active protein.
Manipulation of key genes (once identified) could abolish negative regulation of a given mechanism or enhance expression of certain genes without the need of a light stimulus.
To enlarge the genome design landscape, we allowed the addition of a maximum of three promoters in tandem to modify the regulation of a given operon (ethods).
The results suggest a generalization that while multiple trans-acting factors can each weakly contribute to the total expression regulation of a given gene, a single cis-acting variation plays a far greater role.
However, it still has to be revealed what the exact regulation of a given gene is, i.e. which functional TFBSs are there in its regulatory regions, and which is the original signal that flags a promoter region as such.
In some cases, the magnitude of Ii,j may be interpreted as the strength of up- or down-regulation of a given cellular function i by the environmental factor j (see Methods).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com