Expression of IMPDH II, the rate-limiting enzyme for cellular guanine ribonucleotide biosynthesis, prevents p53-induced asymmetric self-renewal, while leaving p53-dependent gene regulation intact [16], [18], [19].
Our results imply that mutations causing changes in the maximum production rate or the relative decay rate, but keeping the threshold of regulation intact, may have almost no phenotypic signature if the regulatory dose-response relationships are steep enough.
In the end, the regulations remained intact.
But since that time, most lower courts have upheld federal, state, and local gun rules, leaving the country's gun regulations mostly intact, according to Martin J. Siegel, a Houston appellate attorney who practices before the Fifth Circuit.
Draconian regulations kept intact since the 1970s along with rising ticket prices and unexciting restrictor plate races at Talladega and Daytona helped to contribute to the empty seats at NASCAR races in addition to declining TV ratings.
Regulation of outer mitochondrial membrane permeability is a complex process involving both the regulation of intact organelles by Bcl-2 family proteins and the regulation of the collapsed mitochondrion [30], [31].
Katherine Eyres at LexisPSL says: The reforms proposed by the Leveson report are about as palatable as the press and the politicians could have hoped for: a more formidable regulator underpinned by legislation, with self-regulation remaining intact and checks and balances to maintain independence from parliamentary and press interference.
These effects of emotion regulation remained intact even when controlling for baseline social functioning and Big Five personality traits.
The regulation of intact PTH (iPTH) by extracellular calcium has been studied extensively, but the mechanism whereby serum magnesium affects PTH has still not been fully elucidated.
Calorie restriction in WT fish may not result in changes in muscle cellularity because the metabolic signals normally influencing endogenous Gh regulation remain intact, a hypothesis requiring further assessment.
