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Dose rate effects on transcript regulation were observed with both direct and inverse trends.
Significant effects on gene regulation were observed on genes involved in circadian rhythm, kinase activity, vesicular transport and immune response.
Two general patterns of regulation were observed.
Interestingly, differences in adipose tissue gene regulation were observed depending on individual responses to caloric restriction [21].
Clear patterns of gene regulation were observed with significant changes in genes involved in a wide range of processes being seen.
As predicted, almost all the hallmarks of β regulation were observed with PA6 channels: βs increased peak currents >15-fold, shifted activation ∼−10 mV, β2a increased R350, and β3 shifted the h∞ curve (Fig. 3E H, Table 1).
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This potential effect would have implications for, e.g., the time of day when maximum transcript regulation was observed.
An inverse dose rate effect on total transcript regulation was observed in the kidney cortex, liver, and lungs.
OsCOPT7 was expressed in a pattern similar to that of the MAs-related genes (Table 1), although it's up regulation was observed only at 36 h.
Also, a modest increase of pAKT, which is a component of the alternative PI3K pathway involved in cell survival signaling as well as glucose homeostasis regulation, was observed.
Furthermore, regulation was observed for mitochondrion-associated proteins, glycolytic enzymes, a cytoskeleton-associated protein, a nuclear protein and proteins involved in apoptosis.
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