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A remarkable feedback regulation was observed at the early stage of MC treatment when GA biosynthetic and metabolic genes expression was evidently upregulated.
Furthermore, regulation was observed for mitochondrion-associated proteins, glycolytic enzymes, a cytoskeleton-associated protein, a nuclear protein and proteins involved in apoptosis.
An inverse dose rate effect on total transcript regulation was observed in the kidney cortex, liver, and lungs.
This potential effect would have implications for, e.g., the time of day when maximum transcript regulation was observed.
Also, a modest increase of pAKT, which is a component of the alternative PI3K pathway involved in cell survival signaling as well as glucose homeostasis regulation, was observed.
Non-concomitant correlation between production and expression regulation was observed.
Similar(36)
Up-regulation was observed for 178 genes, whereas 370 genes were down-regulated.
However, a delayed 5-fold up-regulation was observed in vivo against Vibrio parahaemolyticus infection at 72 hpi.
Nevertheless, after GHSC-74 exposure, no significant Fas and FasL up-regulation was observed in HepG2 cells by flow cytometry.
Therefore, pERK1/2 down-regulation was observed even at day 3.
Down-regulation was observed in 38% (5 of 14) of ADC samples.
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