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In addition to cell-mediated endocytosis, the IGF system in vivo has another layer of regulation to modulate extracellular levels of IGF1, the IGFBPs [ 27].
Many IDRs that can form such functional aggregates have been shown to be under tight regulation to modulate their availability in the cell.
The possibility of a more comprehensive annotation of ncRNAs in Wolbachia is particularly exciting given recent work suggesting that ncRNAs provide an important layer of posttranscriptional regulation to modulate protein expression levels in the Buchnera endosymbiont of aphids (Hansen and Degnan 2014).
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Rapid synthesis after brief exposure is expected for a signal, while longer irradiation (4 h or longer) could provoke a down-regulation to modulate metabolite levels.
The regulation of the function of RYRs is complex and overall this regulation serves to modulate the sensitivity of RYRs to cellular Ca2+ levels.
Our longitudinal design allowed for examination of two perspectives on the interplay of reactivity and regulation, namely that (a) early negative affectivity interferes with the development of later regulation and (b) regulation is necessary to modulate negative affectivity and, thus, would buffer the effects of negative affectivity on later regulation.
We review how chromatin regulation acts locally to modulate the expression of specific genes and more broadly to coordinate gene expression programs during transitions between cellular states.
This kind of feedback or negative regulation is likely to modulate the remodelling process in vivo after a synergistic or an additive effect because a number of cytokines are simultaneously involved in the mechanically activated periodontal cells.
This regulation is required to modulate gene expression and cell movements that are essential for gastrulation.
A number of microRNAs are known to modulate regulation of crucial oncogenes and function both by promoting as well as suppressing oncogenesis and form a distinct class popularly termed as 'oncomiRs' [8].
We investigated doxycycline-based regulation of gene expression to modulate the secretion of erythropoietin (EPO) from encapsulated myoblasts in a mouse model.
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