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Cytoplasmic dynein mediates spindle orientation from the cell cortex through interactions with astral microtubules, but neither the mechanism governing its cortical targeting nor the regulation thereof is well understood.
Clearly, CREB activation is implicated in addiction, but whether it directly contributes to the acute rewarding effects of drugs or initiates a homeostatic regulation thereof appears less clear.
Overall, however, the lineage specificity of these putative cell populations and regulation thereof remains elusive (Rawlins, 2008).
Among these are compounds of industrial importance, and there is an interest in studying these metabolic pathways on the level of gene expression and regulation thereof.
Several hypotheses relating to mechanisms of nectar production and regulation thereof are proposed, and provide a starting point for reverse genetics approaches to determine molecular mechanisms underlying nectar synthesis and secretion.
Considering that actin-patch formation occurs before filopodia elongation, this argues for a 2-step process where Rac1-induced patch formation (and ArhGAP44-dependent regulation thereof) precedes Cdc42-induced filopodia elongation.
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Fig. 2A shows high expression of flag-tagged mutated eIF2B5 protein compared to endogenous eIF2B5 in DDR1 controls and down-regulation thereof in sh2B5 cells.
Regulations thereof should be harmonized as much as possible, by acknowledging the likelihood that orphan indications may not be properly and timely covered by approval and reimbursement.
Dinosaurian body temperature regulation, or lack thereof, has been a hotly debated topic among students of dinosaur biology.
To address this issue, which is particularly pressing with PHI regulation (or lack thereof), we have developed a strict protocol that delineates the types of sources to query, in which order, for how long, and which response to record in the database at the end of the search.
This paper explores how arborists negotiate their work environment, including the pressures of policies, the labour market, technologies, government regulations and lack thereof, and the non-human agencies with which they are confronted.
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