Although there is no clear idea about the mechanisms that determine the set of miRNAs undergoing this type of regulation, sequencing data show that the majority of miRNAs regulated by Smad contain a consensus sequence within the stem region of the corresponding pri-miRNA, to which Smads bind directly.
The SMC impairment may be also associated with neurological soft signs, describing the neurological abnormalities in sensory integration, motor regulation, sequencing complex motor acts, and primitive reflexes that occur in the majority of schizophrenia patients [ 50].
Some other applications of CGR include the problem of HIV-1 subtype classification [ 19], detection of persistent dynamic of human spike trains [ 20], horizontal transfer detection [ 21], phylogeny and extraction of representative motifs in regulation sequences [ 22], to name a few.
Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in health and disease.
From a functional perspective, genetic variations imply changes in gene regulation (through sequence changes in a regulatory region, or epigenetic changes), changes in coding sequence, or a change in splicing.
The coordinate agent will generate a regulation priority sequence contains neighboring agent equipment based on the received regulation requests and knowledge base information.
As for the regulation priority sequence, the regulation devices within the agent will certainly have the highest priority, and followed by the neighboring agent devices at the same level.
If the voltage stability problem hasn't been eliminated at this time, then the agent regenerates a new regulation priority sequence, which will include the regulation device from the upper agent layer.
These elements function in gene regulation and sequence variation in pathogenic Neisseria [14], [15].
