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After analyzing several BH3-only protein described to be involved in apoptosis (e.g., BAD, BID, BIM, PUMA, and Noxa), only BIM demonstrated CVD-mediated regulation, resulting in substantially up-regulated expression.
This condition then promotes disruption of intracellular calcium regulation, resulting in calcium deposition [23, 34, 35].
Zenefits has been under fire for skirting regulation, resulting in the ouster of its previous CEO Parker Conrad and a heavy-duty overhaul underway of the company.
An important determinant of local population growth is the strength of density regulation resulting from intraspecific competition.
Floodplain landscapes are highly fragmented by river regulation resulting in habitat degradation and flood regime perturbation, posing risks to population persistence.
HDAC inhibitors are thought to act in part by disrupting normal cell cycle regulation, resulting in apoptosis and/or differentiation of transformed cells.
Next, the sender module was integrated into the receivers under positive-feedback regulation, resulting in population density-dependent GFP expression in a quorum-sensing pattern.
Therefore, the frontal regions are balanced and the available right frontal resources allow for greater capacity to attend to cardiovascular regulation, resulting in a decrease in systolic blood pressure and heart rate.
Gene expression studies of this parasite directly obtained from the patients has provided evidence of gene regulation resulting in varying amount of transcript levels in the different blood stages.
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Without Securin regulation, Separase is well regulated in all kinds of cells in vivo [30], [42] [45], whereas Separase functions poorly in PGCs without phospho-regulation, resulting in the premature segregation of sister chromotids and other chromosome segregation errors, including chromosome misalignment and mis-segregation.
Very low doses can stimulate the production of more receptors (receptor up-regulation), resulting in an increase in responses, whereas higher doses (within the typical toxicologic range of chemical testing) can inhibit receptors (receptor down-regulation), resulting in a decrease in responses (Welshons et al. 2003).
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