Although in vivo experimental studies are the most accurate method for identifying the toxic effects induced by a xenobiotic, time and cost associated with them for new chemical regulation renders them ineffective for regulatory risk assessment.
It has been proposed that evolution may have favoured the differentiation of mechanisms for ABA down-regulation rather than up-regulation, rendering more difficult for any ABA-repression motif to achieve statistical significance [ 16].
Since 1997, more than 20 insurance companies have fled the state, claiming New Jersey's labyrinthine regulations rendered the market unprofitable.
The discretionary and often arbitrary nature of such regulations rendered any specific guarantee of equal trading opportunity impossible.
The 2011 LMP2 regulations rendered the RS Spyder obsolete due to the costs exceeding the LMP2 budget limit.
Lastly, Tai Loong had argued, even if the KD II was a fishing vessel under the statute, the interplay between two sections of the SFPA and its implementing regulations rendered them unconstitutionally vague, making it impossible for it to easily determine whether the statute applied to the KD II.
"Although the government proposes targets for food companies to reduce the level of sugar in their products, the fact that these are voluntary and not backed up by regulation, renders them pointless.
A newly introduced regulation renders the discarding of certain commercially important species illegal within the European waters progressively until 2019 (Article 15, EC Regulation 1380/2013).
Nevertheless, although AS represents a key tool to control gene expression in higher organisms, the extreme flexibility and multilayer nature of its regulation render it error prone and susceptible to alterations that threatens the maintenance of cellular homeostasis.
Our results show that the signaling events leading to eicosanoid and cytokine production are likely to take very different regulation routes, rendering inflammation treatment in CF especially complex.
Up to 200 Australian couples may be affected by Thailand's new regulations, effectively rendering them "pawns in a disastrous game", a leading surrogacy lawyer told the Guardian.
