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In the resulting network, connections between proteins or proteins complexes were deliberately limited to the following relations: "binding", "regulation" (positive or negative) and "phosphorylation" [90].
The number of possible structures regarding cross-talk and feedback is 81 ( = 34) since there can be three kinds of regulation (positive, negative, or not present) for each of four interactions, ERK to Raf-1 (steps 13 and 15), ERK to B-Raf (steps 16 and 18), Raf-1 to B-Raf (steps 17 and 19), and B-Raf to Raf-1 (steps 12 and 14).
Several forms of gene regulation, positive and negative, that involve plant introns were found [ 73].
Therefore, for pathway-involved events, we only consider regulation, positive regulation and negative regulation.
These interactions cover three types of protein metabolism (specifically, gene expression, transcription and protein catabolism), phosphorylation, localization, binding and regulatory events (regulation, positive regulation and negative regulation).
Finally, the feedback (FB) motif involves stimulation of a reaction by a signal, followed by end-product regulation (positive or negative) of the process.
Similar(46)
Our results show that the p53 spontaneous pulses are due to intrinsic DNA double strand breaks in normal proliferating cells, and p53 auto-regulation (positive feedback loop) allows threshold activation of p53 in generating these pulses.
It is possible that like miR-26b, a suite of other HU-responsive miRNAs could modulate HbF production through regulation of positive and negative regulators of γ-globin.
This may explain why its down-regulation causes a positive regulation of the response to hypoxia.
She described barristers' chambers as "little islands" that would be unwilling to conform to any kind of new regulation on positive action.
Activity in these regions has been reported in previous studies on the regulation of positive emotion [31], [53].
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