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These genetic variants, which modify the regulation or function of the mediators, have been associated with susceptibility and/or outcome of severe sepsis and septic shock.
Cdr2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration, but little is known of its regulation or function in cancer cells.
AID are caused by an immune reaction against self antigens due to disturbances in T or B cell regulation or function, and autoimmunity may occur in a genetically susceptible individual if an antigen is inadvertently targeted by T or B cells potentially due to environmental or other factors triggering a break in tolerance [2].
It remains to be tested if the inching phenotype is due to cilia regulation or function.
Little is known of the expression, regulation or function of the DUSPs in human neoplasia.
Usually they have minor effects on the regulation or function of proteins, but these subtle changes might very well have important consequences for susceptibility to disease.
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Though several melanin- and capsule-related genes were up-regulated in the high virulent strain R265, regulation or functions of homologous genes may differ between C. neoformans and C. gattii [28], [29].
Extrapituitary prolactin (Prl) is produced in humans and rodents; however, little is known about its in vivo regulation or physiological function.
However, its mechanism of transcriptional regulation or its function in tumor angiogenesis is unknown.
Rather, they have an expected association with 'functional' polymorphisms involved in the regulation or the function of the IFNλ3 gene product.
Those SNPs, which alter gene regulation or protein function, might not only be useful as biomarkers but also identify new targets for therapy.
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