Sentence examples for regulation of sensitivity from inspiring English sources

Recently, it has been reported that O-glycosylation of TRAILR1 (DR4) and TRAILR2 (DR5) plays a central role in regulation of sensitivity and resistance of cells towards TRAIL-induced apoptosis [24].

Although we have shown that PTK6 expression is critical for anchorage-independent survival of representative cell lines of these subtypes, the full range of functions attributable to PTK6 expression in these specific subtypes (e.g. regulation of sensitivity to chemotherapy or endocrine therapy, proliferation) remains to be addressed.

Thus, the regulation of sensitivity to tamoxifen is influenced by both oncogenic and tumor suppressive miRNAs.

These studies may not only provide deeper insights in the pathophysiology of human inflammatory disorders, but may also help to understand the complex physiological regulation of sensitivity and tolerance of the innate immune system during the life-long interaction with the commensal flora.

Although BAX homologues are not identified in P. anserina yet, several other key factors involved in regulation of sensitivity towards apoptosis elicitation are found in this ascomycete (e. g., metacaspases [ 33], apoptosis-inducing factors and homologues [ 34], the mitochondrial fission protein PaDNM1 [ 7, 8] and the mitochondrial peptidyl prolylcis, transisomerase cyclophilin D [ 35, 36]).

To investigate the importance of Bid or Bim in the regulation of sensitivity and resistance towards apoptosis induction in HTLV-1-infected T cells, we transiently transfected expression plasmids containing either Bid or Bim cDNA into the HTLV-1-infected T-cell lines MT-2 and Hut-102.

Furthermore, microarray analysis also showed that IRS3, AKT2 and GLUT4, three genes that are crucial for the regulation of insulin sensitivity, were significantly up-regulated (Additional file 2).

The acute and chronic actions of EtOH on regulation of autoreceptor sensitivity of pDAergic VTA neurons may be important for determining initial sensitivity as well as chronic response of these neurons to EtOH.

Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction.

However, the effect of IGF-I on the regulation of insulin sensitivity in the adipose tissue is yet unclear.

Resistin and adiponectin are two adipokines involved in the regulation of insulin sensitivity, and have been suggested as mediators of adult metabolic syndrome.