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A second cell-autonomous output of the daf-2 pathway is the regulation of FIRE response sensitivity in intestinal cells [8].
In combination with the other analyses, information from such variant colonies is expected to aid progress in connecting the genetic and phenotypic variation underlying regulation of fire ant social behavior.
Moreover, we conclude that available information on insect OBPs (the protein family to which GP-9 belongs), on the evolutionary/population genetics of Gp-9, and on pheromonal/behavioral regulation of fire ant colony queen number cannot be used to support their conclusion that GP-9 plays no role in the chemosensory-mediated communication that underpins worker regulation of social organization.
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Timing regulation of firing, on the other hand, appears to be related to cell type-specific intrinsic chromatin architecture in nuclei.
This type of regulation of firing rates in response to repetitive acoustic stimuli in the MGB may be similar to what is observed in stimulus specific adaptation in the IC and AC [36], [37], [38].
Because synaptic activity is considered the major determinant of metabolic cost, a conserved energy budget per neuron has several profound implications for synaptic homeostasis and the regulation of firing rates, synaptic plasticity, brain imaging, pathologies, and for brain scaling in evolution.
10.7554/eLife.04378.005 Figure 2. Homeostatic regulation of firing rates is more precise at the network, than the single-unit level.
10.7554/eLife.04378.010 Figure 3. Calcium imaging confirms more precise homeostatic regulation of firing rates at the network, than the single-unit level.
This commissural influence might manifest itself in one of two ways, either as a global regulation of firing, or as differential changes in the firing patterns of different unit types, indicating more functionally specific control.
Upon arrival of strong excitatory input, self-regulation of firing rates is evident by the fact that the synaptic strengths of all synapses of the stimulated cell are reduced while maintaining the relative distribution of synaptic weights across the cell.
Accordingly, our study shows that spatiotemporal regulation of lightning fire initiation through harvesting activity results in a systematic accelerated frequency of disturbance that is novel to the mixedwood boreal system, but the area affected by these events amount to local peculiarities rather than broad-scaled regularities.
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