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Precisely regulated signal transduction pathways are crucial for the regulation of developmental events and prevention of tumorigenesis.
Notably, the proportion of up-regulated genes related to amino acid transport and positive regulation of developmental process was also significantly higher than expected by chance.
Each cluster regulates a different function, including cell motility, biosynthesis of the motility apparatus, or regulation of developmental genes [ 21- 25].
Paper: "Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage".
Here we review evidence of roles for NF-κB in the regulation of developmental and synaptic plasticity, and cell survival in physiological and pathological settings.
In synergy with the regulation of protein abundance or activity, cytoskeletal elements are key contributors to cell cycle progression through spatial regulation of developmental processes.
Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of developmental process".
Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of developmental process".
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses.
We discuss maternal control of the early embryonic epigenetic landscape, selective usage of enhancer clusters via 3D chromatin contacts leading to activation of transcription factor networks, and conserved regulation of developmental pathways by specific DNA demethylation of key regulatory regions.
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We suggest that down-regulation of developmental transcription factors may mediate the aberrant differentiation in ccRCC.
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