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Pre- and post-HIRREM measures included the Rivermead Post-Concussion Symptoms Questionnaire (RPQ, n = 12), the Insomnia Severity Index (ISI, n = 15), the Center for Epidemiologic Studies Depression Scale (CES-D, n = 10), short-term blood pressure and heart rate recordings for measures of autonomic cardiovascular regulation (n = 15), and reaction time by the drop-stick method (n = 7).
This group of genes was significantly enriched for genes involved in mRNA transcriptional regulation (n = 121; p<0.005), particularly for KRAB box transcription factors (n = 84; p<0.002).
Experimental handling of mice was in accordance with institutional guidelines and EEC regulation n. 86/609/CEE.
The Kaplan-Meier curves for patients with normal (n = 119) or abnormal glucose regulation (n = 105) classified by an OGTT in-hospital are shown in Figure 1A.
Top biological process categories included transcriptional regulation (n = 1052), transport (n = 899), signal transduction (n = 475), organismal development (n = 469), and metabolic processes (n = 448, Figure 2).
Of great importance, it was discovered that the PGR protein follows the same expression pattern as the PGR gene after E2-exposure showing a sex-specific regulation (n = 8, interaction P = 0.0028).
Similar(47)
Using a p-value cutoff of 0.05, the number of probes indicating up-regulation (n up ) and down-regulation (n down ) were tallied by probe set.
TFs were grouped into four regulatory types: those with "no auto-regulation" (N = 70), "negative auto-regulation" (N = 64), "positive auto-regulation" (N = 26), and "dual auto-regulation" (N = 9, where both positive and negative auto-regulation have been reported) based on their annotation in RegulonDB.
Three discrete functional states were defined as 1) up-regulation (u, by ≥ 2 fold and FDR ≤ 0.05), 2) down-regulation (d, by ≥ 2 fold and FDR ≤ 0.05), and 3) no-regulation (n).
- Three interventions covered the creation of an enabling environment, by decentralisation of HRM functions (n = 2) and by regulations (n = 1).
Eighty-six percent of respondents reported that the Code has not had any meaningful impact on their country's health workforce recruitment practices, policies or regulations (n = 36).
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