When regulations malfunction - either by doing too much or too little - people feel the impact directly.
Epigenetic modifications have an important role in gene expression regulation, and malfunctioning of the regulation process can have severe consequences.
Furthermore, injection of dsRNA targeting genes encoding a calcium-binding protein calreticulin and a gut cathepsin, and feeding dsRNA of a water-specific aquaporin gene in artificial diet assay led to the down-regulation and malfunction of these targeted genes in A. pisum, although the target gene expression knockdown didn't exceed 50% and was transient, persisting for less than a week [ 24, 25].
These mainly include contamination/infection, device malfunction and regulation of the industry.
Our data supports a novel function of MID1 in directing mRNP complex-associated protein translation regulation to the cytoskeleton, malfunction of which would explain the observed developmental malformations in OS.
The requirement of Dop for dynein-dependent transport and normal phosphorylation of Dic suggested that the cellularisation defects in dop mutants might be related to a malfunction in dynein regulation.
Unstable gene regulations will lead to the malfunction or even the death of the cells.
Malfunctioning of GTPase regulation has implications in numerous human diseases, in particular in cancer formation and propagation.
As a consequence of their multiple roles in the regulation of gene expression, any malfunctioning, especially with respect to their deregulated expression in cancer, is expected to affect the physiological network of RNA-RBP interactions [ 5, 6].
It has now been broadly accepted that malfunction of the neural regulation of metabolism could lead to obesity, type 2 diabetes and other profound metabolic disorders (Friedman and Halaas, 1998; Gautron et al., 2015; Myers and Olson, 2012).
