To further explore the regulation of mPGES-1 and related PGE2-synthesizing enzymes in gingival fibroblasts, we here used a global gene expression profiling approach to achieve a broader view of the genes and signal pathways related to the regulation of mPGES-1, in parallel with COX-2, using microarray analysis of TNFα-treated gingival fibroblasts.
Cygb up regulation during fibrogenesis occurs in parallel with changes in collagen expression in both the liver and the kidney [ 17, 27, 28], and Cygb knockout mice show reduced levels of liver fibrosis and ECM deposition following insult with carbon tetrachloride.
Thus, in parallel with regulation of starvation-induced Beclin 1 S90 phosphorylation, MK2 regulates starvation-induced autophagy.
The factors that restrict COH-3/4 cohesin to the short arm are not known, but could include HTP-1/2, LAB-1, and PP1; however, if these factors regulate the distribution of COH-3/4 cohesin, they must do so in parallel with their regulation of AIR-2.
A recent proteomics study also reported significant up-regulation of TAG-related acyltransferases in parallel with accumulation of large quantities of lipid in C. vulgaris cultured under nitrogen limitation [ 13].
Abundance of transcripts categorized to stress response, development, and signaling mechanisms, compared in parallel with protein regulation.
Here, we found that NFAT activity is increased in parallel with SERCA regulation at short time intervals (6 h) and may therefore be important for an adaptive hypertrophic response.
We showed that the up-regulation of H3K4me1/3 markers usually associated with active chromatin occurs in parallel with the down-regulation of H3K27me3 by TGFβ1, suggesting that those regulatory mechanisms can further contribute to the increased gene expression.
PD-L1 expression exhibits a similar dynamic pattern in patients with chronic hepatitis B. The expression of PD-L1 on circulating CD11c + mDCs increased during the initial phase of liver inflammation (T1) and reached peak levels in parallel with up-regulation of the frequency of PD1 expression on circulating CD8+ T cells in the T2 period.
Slight induction of putative bile salt transporter (multidrug resistance associated protein, up 2.6-fold) was in parallel with down-regulation of genes for carriers of lipids including several apolipoproteins (2- to 5-fold down-regulated) and sterolin (cholesterol), steroids and retinoids (lipocalin), triglycerides and fatty acids.
