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The genes whose expression changed during differentiation globally displayed the same regulation in control cells and in HP1γ knockdown cells but with a notably higher amplitude (Figure 5B, clusters a and c).
Similarly, miRNA regulation in control cells over time was determined by comparing expression levels at different time points and 0 hr.
To decipher the RhoB implication in trastuzumab effects, we chose to study its expression regulation in control cells (OVACR-3A and WT) by its upexpression (Adeno-RhoB) and in the long-time exposed derived cells its inhibition (OVCAR-3LTE, shRNA RhoB).
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In this work I concentrated on this problem and revealed a second level of regulation in controlling Robo signalling.
This study identifies the critical role for osteoclast autocrine regulation in controlling long-term dynamic of osteoclast formation and death and describes the complementary roles for negative and positive feedback mediators in determining the sharp dynamics of activation and inactivation of osteoclasts.
In this review, we will summarize how circadian genomics have revealed new insights into rhythmic post-transcriptional regulation in mammals and discuss potential implications of such regulation in controlling many circadian-driven physiologies.
Asexual-stage development is tightly regulated, and large-scale studies of transcription have emphasized a key role for gene regulation in controlling this process (Bozdech et al., 2003; Lasonder et al., 2002; Otto et al., 2010).
We accessed the entire microarrays dataset available on the Gene Expression Omnibus database (GSE33799) and its inspection revealed a 1.8-fold1.8-folded P-value 1.24 × 10−9) FRG1 up-regulation in control muscle cells ectopically expressing DUX4.
PvTIFY10C would act as a transcriptional activator of genes that showed induction in control roots and repression in silenced roots and conversely, would act as a transcriptional repressor of genes that showed down-regulation in control and over-expressing roots and induction in silenced roots under P-deficiency.
For CLF2, a similar analysis indicated a 2-fold mean difference in protein level in Figure 4F with all 8 cell lines from Figure 4E F confirming the direction of regulation (higher in control).
This study highlights the potentials of runoff self-regulation in controlling soil erosion and sediment delivery.
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