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As a conclusion, the TPE associated with SAg silencing and activation cannot be explained by a simple spreading of telomeric heterochromatin into subtelomeric regions, rather it seems more likely that the TPE influences SAg regulation in combination with a gene specific factor to specifically regulate one individual locus, thus avoiding global spreading events.
Recent advances in the understanding of phytoalexin function, biosynthesis and regulation, in combination with novel methods of molecular engineering and advances in instrumental analysis, returned attention to phytoalexins as a potent target for improving crop protection.
While an appreciation of actin dysregulation as a potential contributor to neurodegenerative disease is just beginning, this study illustrates the severe consequences of altered actin regulation in combination with other defects.
To obtain a general idea on the method at hand, the reader simply can consult the meta-data fields "Title", "Evaluation", "Status", and "Regulation", in combination with the abstract section "3R relevance".
DOI: http://dx.doi.org/10.7554/eLife.05338.019 Finally, to further assess the efficiency of protein knockdown through temperature regulation in combination with the deGradFP system, we preformed western blots against GFP for three other genes.
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Preliminary results of down-regulation in combination with a cytotoxic therapy however do suggest that targeting FRS2 and FRS3 may be specifically effective in cancer cells.
Only two projects are successfully put into operation by Ray Power Company in the power grid of North China, and both of them participate in frequency regulation service in combination with thermal power plant.
We conclude that employing epigenetic gene regulation tools, in combination with further process optimization, might represent the next step forward in the production of therapeutic proteins.
Therefore in isolation these events will not provide population regulation, but in combination with other stochastic environmental events and density-dependent feedbacks, they may play a role in population limitation.
Sequence-specific RBPs play important roles in translational regulation, sometimes in combination with microRNAs (miRNAs) [ 7 9].
We suggest that upregulation of RAD21 expression may be required for promoting CIN, either directly by favouring hyper-recombination or indirectly, via dysregulated chromosome segregation or by promoting global gene de-regulation, or in combination.
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