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The interaction between an active kinase and an 'inactive' pseudokinase provides clues about how these enzymes were regulated in the past, and how this regulation has evolved.
From single regulators to complex mRNPs to genome-wide studies, research on RBP-mediated regulation has evolved in highly complementary, parallel directions that promise to converge to allow accurate predictions of systems behavior.
Environmental regulation has evolved since its establishment in the 1960s.
The process of drug regulation has evolved over time.
The empirical study of economic regulation has evolved considerably since George Stigler's seminal work in 1962.
It will be described how the regulation has evolved from a pure Feed-in-Tariff to a market+premium option, where technical and economic integration has been a priority.
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Mr. Gensler could not be reached for comment about how his views about financial regulation have evolved.
Contemporary research ethics, and corresponding research regulation, have evolved in response to the historical abuses perpetrated by researchers against research participants—including the German wartime experiments on prisoners, the infamous Tuskegee Study, and the Jewish Chronic Disease Case in the name of furthering generalizable knowledge.
However, given the overwhelming evidence for a high degree of conservation in vesicle trafficking principles from yeast to human, especially for SNARE dependent mechanisms [1], [2], it seems more likely that in neurons additional layers of regulation have evolved to control docking and to accommodate the specific features of synaptic transmission.
Even if there is no necessary biochemical tendency in this direction, it is possible that pathways and their regulation have evolved to promote such interactions.
Air transportation regulations have evolved considerably since 1963 and part 135 has been the subject of numerous rule making proceedings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com