Sentence examples for regulation functionality from inspiring English sources

The approach described in this paper is based on a model that is both feasible in terms of running relatively complex evolutionary simulations and includes a biologically plausible gene-protein regulation functionality with an integrate-and-fire neural mechanism.

PRMT5 has also been shown to methylate NF-κB, promoting its gene regulation functionality in a colon cancer cell model.

Toward this, we utilized split-Cas9 systems to develop a modular adeno-associated viral (AAV) vector platform for CRISPR-Cas9 delivery to enable the full spectrum of targeted in situ gene regulation functionalities, demonstrating robust transcriptional repression (up to 80%) and activation (up to 6-fold) of target genes in cell culture and mice.

Both compound-specific and common gene expression changes were observed between subsets of tested compounds, in terms of significance, magnitude of regulation and functionality.

Based on findings in model organisms, indicating that network structure such as dynamic modularity [14] and topological cartography [15] determined the key aspects of regulation and functionality, we developed a new framework of network topological analyses to estimate the implied pathological effect for each gene in the HNSCC transcriptome.

However previous studies have reported conflicting results on the regulation and functionality of this heterodimer in response to genotoxic agents which induce (i) DNA adducts other than DSBs, and therefore also (ii) unique signaling pathways relative to the situation for IR (see Introduction).

Increasing evidence indicate that voltage-gated K+ (Kv) channels are involved in the regulation of microglia functionality.

During plant development they are involved in the regulation of protein functionality and the breakdown of storage compounds in the seed and other plant tissues [ 3– 5].

Antisense transcription was also evident during early germination suggesting that NATs participate in the regulation of changing functionalities at this critical period of conidial outgrowth.

Several association studies have investigated genetic variants that may alter the functions of genes involved in serotonin functionality and regulation.

On the other hand, drawbacks include the difficulty of predicting transcription factor binding in mammals, lack of knowledge of gene functionality and regulation, and the inability to measure post-transcriptional regulation.